CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol
نویسندگان
چکیده
Marco Mancini, Daniela Scappaticci, Giuseppe Cimino, Mauro Nanni, Valentina Derme, Loredana Elia, Agostino Tafuri, Marco Vignetti, Antonella Vitale, Antonio Cuneo, Gianluigi Castoldi, Giuseppe Saglio, Fabrizio Pane, Cristina Mecucci, Andrea Camera, Giorgina Specchia, Alessandra Tedeschi, Francesco Di Raimondo, Giuseppe Fioritoni, Francesco Fabbiano, Filippo Marmont, Felicetto Ferrara, Nicola Cascavilla, Giuseppe Todeschini, Francesco Nobile, Maria Grazia Kropp, Pietro Leoni, Antonio Tabilio, Mario Luppi, Luciana Annino, Franco Mandelli, and Robin Foà
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMAALL 0288 randomized study
The GIMEMA ALL 0288 trial was designed to evaluate the impact of a 7-day prednisone (PDN) pretreatment on complete remission (CR) achievement and length, the influence of the addition of cyclophosphamide (random I) to a conventional 4-drug induction on CR rate and duration, and whether an early post-CR intensification (random II) by an 8-drug consolidation could improve CR duration. Median foll...
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The BCR-ABL fusion, the molecular equivalent of the Philadelphia translocation, gains importance for treatment stratification in adult acute lymphoblastic leukemia (ALL). In this prospective study, samples from 478 patients with CD101 B-cell precursor ALL (c-ALL and pre-B ALL) underwent BCR-ABLreversetranscription–polymerase chain reaction (RT-PCR) analysis with double testing of positive sampl...
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Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspects of epigenetics, which control leukemogenesis in pediatric ALL, mainly DNA methylation, histon...
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6-Mercaptopurine (6MP) and methotrexate are the backbone of continuation therapy for childhood acute lymphoblastic leukemia (ALL). In studies of oral 6MP and methotrexate, indices of chronic systemic exposure to active metabolites of these agents, namely, red blood cell (RBC) concentrations of methotrexate polyglutamates (MTXPGs) and thioguanine nucleotides (TGNs) have positively correlated wit...
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